Going blow thru will work just fine. Lots of people do it, just look around at Turbomustangs.com forums and you will see lots of folks doing it, and LOTS of DIY turbo related info / fab tips, etc. I dont' mean to point you there as this site is awesome too, just letting you know about more info. For me, it's about sharing info.
For the carb, The key is in the air bleeds and PVCRs. if you are familiar with tuning these, then a little searching and reading will tell what you need to do to finetune your app. Starting off with a BT carb is a good start as well.
As far as manifolds I can't really say. Bigger runners normally want a higher engine speed or higher displacement to get the velocity up (NA). You're going to be injesting more densely packed air while boosted, so it seems a larger runner would be able to handle that better? Don't know. I do know that most folks find a single plane manifold to work better and tune easier than a dual place, though there has been some success with the RPM Air-Gap I think. Distribution is key when in boost as cylinders a little lean will probably show up quicker than in a NA application.
Water / alky injection is an awesome addition to boosted engines, especially if you don't have room / don't want intercoolers. There's lots of discussion on that topic everywhere of course.
Pay attention to what carb hat you use, how much spacer you put on top, keep vent tube extensions in mind, and make sure you use a boost ref. fuel regulator and plenty of pump.
Good luck!